Ketamine Facts

Ketamine therapy has emerged as a promising treatment for treatment-resistant depression (TRD), offering rapid relief for individuals who have not responded to traditional antidepressants. Unlike conventional medications that primarily target serotonin and norepinephrine, ketamine acts on the glutamate system, specifically blocking NMDA receptors. This mechanism enhances synaptic plasticity and promotes the formation of new neural connections, contributing to neuroplasticity—the brain’s ability to adapt and reorganize.

Neuroplasticity and Receptor Activity

Ketamine’s antidepressant effects are linked to its ability to increase Brain-Derived Neurotrophic Factor (BDNF), which supports neuronal growth and resilience. Studies suggest that ketamine rapidly enhances neuroplasticity, leading to structural changes in key brain regions associated with mood regulation, such as the prefrontal cortex and hippocampus.

Benefits of Combined Psychotherapy and Infusions

While ketamine infusions alone can provide relief, combining them with psychotherapy enhances long-term outcomes. Ketamine creates a “window of neuroplasticity” , allowing patients to engage in deeper therapeutic work while their brain is more adaptable. Ketamine-assisted psychotherapy (KAP) leverages this effect, helping individuals process emotions, reframe negative thought patterns, and integrate insights gained during treatment.